Article

History of NAD+

An educational overview of NAD+, its biological role, the history of NAD+ IV infusions, and potential areas of research interest.

What is NAD+?

Nicotinamide adenine dinucleotide is a molecule found in living cells. NAD+ is the more reactive form and plays a key role in metabolism, biochemical reactions, cellular communication, and biological processes across the body.

History and IV therapy

NAD+ was first documented in 1906 during research into alcohol fermentation. Over the following century, scientists continued uncovering its biological functions. In recent decades, NAD+ IV therapy became a topic of medical and wellness interest, including work popularized by Paula Norris Mestayer.

Potential benefits discussed

  • Healthy aging, mitochondrial function, cell growth, energy, inflammation, metabolism, and lifespan research.
  • Age-related and neurodegenerative conditions including Parkinson's disease, Alzheimer's disease, multiple sclerosis, fibromyalgia, and mitochondrial dysfunction.
  • Mental health and chronic illness areas such as depression, anxiety, PTSD, chronic stress, chronic fatigue, and addiction treatment support.
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